Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability

Paclitaxel is a frontline drug for the treatment of epithelial ovarian cancer (EOC). However, following paclitaxel-platinum based chemotherapy, tumor recurrence occurs in most ovarian cancer patients. Chromosomal instability (CIN) is a hallmark of cancer and represents genetic variation fueling tumo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neoplasia
Auteurs principaux: Raab, Monika, Sanhaji, Mourad, Zhou, Shengtao, Rödel, Franz, El-Balat, Ahmed, Becker, Sven, Strebhardt, Klaus
Format: Artigo
Langue:Inglês
Publié: Neoplasia Press 2019
Sujets:
Original article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407080/
https://ncbi.nlm.nih.gov/pubmed/30851646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2019.01.007
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