Activation of CD8(+) T Cell Responses after Melanoma Antigen Targeting to CD169(+) Antigen Presenting Cells in Mice and Humans

The lack of tumor-reactive T cells is one reason why immune checkpoint inhibitor therapies still fail in a significant proportion of melanoma patients. A vaccination that induces melanoma-specific T cells could potentially enhance the efficacy of immune checkpoint inhibitors. Here, we describe a vac...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: van Dinther, Dieke, Lopez Venegas, Miguel, Veninga, Henrike, Olesek, Katarzyna, Hoogterp, Leoni, Revet, Mirjam, Ambrosini, Martino, Kalay, Hakan, Stöckl, Johannes, van Kooyk, Yvette, den Haan, Joke M. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406251/
https://ncbi.nlm.nih.gov/pubmed/30764534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11020183
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