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Selective tumor antigen vaccine delivery to human CD169(+) antigen-presenting cells using ganglioside-liposomes
Priming of CD8(+) T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine carrier that delivers tumor antigens to human CD169/Siglec-1(+) antigen-presenting cells using gangliosides as targeting ligands. Gangliosid...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7959579/ https://ncbi.nlm.nih.gov/pubmed/33067394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006186117 |
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