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p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury
p38α MAPK negatively regulates the G(1)/S and G(2)/M cell cycle transitions. However, liver-specific p38α deficiency impairs cytokinesis and reduces hepatocyte proliferation during cirrhosis and aging in mice. In this work, we have studied how p38α down-regulation affects hepatocyte proliferation af...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6405944/ https://ncbi.nlm.nih.gov/pubmed/30846722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39428-3 |
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