Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4-Mediated Downregulation of PPARγ/LXRα/ABCA1 in ApoE(-/-) Mice

Background: Although our previous studies have confirmed that the activation of TLR4 is implicated in the development of atherosclerosis induced by chronic unpredicted mild stress (CUMS), the underling mechanism is largely unclear. Here, we hypothesized that CUMS accelerates atherosclerotic developm...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Gu, Hong-Feng, Li, Na, Xu, Zhao-Qian, Hu, Lu, Li, Hui, Zhang, Rong-Jie, Chen, Ru-Meng, Zheng, Xi-Long, Tang, Ya-Ling, Liao, Duan-Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405526/
https://ncbi.nlm.nih.gov/pubmed/30881312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00165
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