Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4-Mediated Downregulation of PPARγ/LXRα/ABCA1 in ApoE(-/-) Mice

Background: Although our previous studies have confirmed that the activation of TLR4 is implicated in the development of atherosclerosis induced by chronic unpredicted mild stress (CUMS), the underling mechanism is largely unclear. Here, we hypothesized that CUMS accelerates atherosclerotic developm...

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Опубликовано в: :Front Physiol
Главные авторы: Gu, Hong-Feng, Li, Na, Xu, Zhao-Qian, Hu, Lu, Li, Hui, Zhang, Rong-Jie, Chen, Ru-Meng, Zheng, Xi-Long, Tang, Ya-Ling, Liao, Duan-Fang
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2019
Предметы:
Physiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405526/
https://ncbi.nlm.nih.gov/pubmed/30881312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00165
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