Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE(−/−) mice by downregulating the HMGB1-RAGE axis

AIM: High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play pivotal roles in vascular inflammation and atherosclerosis. The aim of this study was to determine whether the HMGB1-RAGE axis was involved in the actions of simvastatin on vascular inflamm...

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Detalhes bibliográficos
Main Authors: Liu, Ming, Yu, Ying, Jiang, Hong, Zhang, Lei, Zhang, Pei-pei, Yu, Peng, Jia, Jian-guo, Chen, Rui-zhen, Zou, Yun-zeng, Ge, Jun-bo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002903/
https://ncbi.nlm.nih.gov/pubmed/23564080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.8
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