Single-cell RNA-Seq of follicular lymphoma reveals malignant B-cell types and coexpression of T-cell immune checkpoints

Follicular lymphoma (FL) is a low-grade B-cell malignancy that transforms into a highly aggressive and lethal disease at a rate of 2% per year. Perfect isolation of the malignant B-cell population from a surgical biopsy is a significant challenge, masking important FL biology, such as immune checkpo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Andor, Noemi, Simonds, Erin F., Czerwinski, Debra K., Chen, Jiamin, Grimes, Susan M., Wood-Bouwens, Christina, Zheng, Grace X. Y., Kubit, Matthew A., Greer, Stephanie, Weiss, William A., Levy, Ronald, Ji, Hanlee P.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2019
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405336/
https://ncbi.nlm.nih.gov/pubmed/30591526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-08-862292
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