Self-glycerophospholipids activate phospholipid-reactive T cells, and interfere with iNKT cell activation by competing with iNKT cell ligands for CD1d loading

Glycosphingolipids and glycerophospholipids bind CD1d. Glycosphingolipid-reactive invariant NKT-cells (iNKT) exhibit myriad immune effects, however, little is known about the functions of phospholipid-reactive T-cells (PLT). We report that the normal mouse immune repertoire contains αβ T-cells, whic...

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Publicado no:Eur J Immunol
Main Authors: Halder, Ramesh Chandra, Tran, Cynthia, Prasad, Priti, Wang, Jing, Nallapothula, Dhiraj, Ishikawa, Tatsuya, Wang, Meiying, Zajonc, Dirk M., Singh, Ram Raj
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405219/
https://ncbi.nlm.nih.gov/pubmed/30508304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201847717
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