A Single Agent Dual Specificity Targeting of FOLR1 and DR5 as an Effective Strategy for Ovarian Cancer

Therapeutic antibodies targeting ovarian cancer (OvCa)-enriched receptors have largely been disappointing due to limited tumor specific antibody-dependent cellular cytotoxicity (ADCC). Here we report a symbiotic approach that is highly selective and superior compared to investigational clinical anti...

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Vydáno v:Cancer Cell
Hlavní autoři: Shivange, Gururaj, Urbanek, Karol, Przanowski, Piotr, Perry, Justin S.A., Jones, James, Haggert, Robert, Koska, Christina, Patki, Tejal, Stelow, Edward, Petrova, Yuliya, Llaneza, Danielle, Mayo, Marty, Ravichandaran, Kodi S., Landen, Charles N., Bhatnagar, Sanchita, Tushir-Singh, Jogender
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404966/
https://ncbi.nlm.nih.gov/pubmed/30107179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.07.005
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