Staphylococcus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand sequestration

Staphylococcus aureus Panton-Valentine leukocidin is a pore-forming toxin targeting the human C5a receptor (hC5aR), enabling this pathogen to battle the immune response by destroying phagocytes through targeted lysis. The mechanisms that contribute to rapid cell lysis are largely unexplored. Here, w...

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Pubblicato in:FASEB J
Autori principali: Haapasalo, Karita, Wollman, Adam J. M., de Haas, Carla J. C., van Kessel, Kok P. M., van Strijp, Jos A. G., Leake, Mark C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404581/
https://ncbi.nlm.nih.gov/pubmed/30509126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801910R
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