Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCα-dependent manner

Excessive iron increases the incidence of diabetes and worsens diabetic complications. Reciprocally, diabetes induces iron loading, partially attributable to elevated intestinal iron export according to a recent report. Herein, we show that iron uptake and the mRNA expression of iron importer divale...

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Publicat a:FASEB J
Autors principals: Zhao, Luqing, Bartnikas, Thomas, Chu, Xiangpeng, Klein, Janet, Yun, Chris, Srinivasan, Shanthi, He, Peijian
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404579/
https://ncbi.nlm.nih.gov/pubmed/30423260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801855R
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