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Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA(2) in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia

Lysophosphatidic acid (LPA) acts on LPA(2) receptor to mediate multiple pathological effects that are associated with tumorigenesis. The absence of LPA(2) attenuates tumor progression in rodent models of colorectal cancer, but whether overexpression of LPA(2) alone can lead to malignant transformati...

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Publicat a:PLoS One
Autors principals: Yoshida, Michihiro, He, Peijian, Yun, C. Chris
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849659/
https://ncbi.nlm.nih.gov/pubmed/27124742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154527
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