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Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA(2) in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia
Lysophosphatidic acid (LPA) acts on LPA(2) receptor to mediate multiple pathological effects that are associated with tumorigenesis. The absence of LPA(2) attenuates tumor progression in rodent models of colorectal cancer, but whether overexpression of LPA(2) alone can lead to malignant transformati...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4849659/ https://ncbi.nlm.nih.gov/pubmed/27124742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0154527 |
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