Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia

BACKGROUND: The tumor suppressor protein phosphatase and tensin homolog (PTEN) is a key regulator of the PI3K/AKT pathway which is frequently altered in a variety of tumors including a subset of acute B-lymphoblastic leukemias (B-ALL). While PTEN mutations and deletions are rare in B-ALL, promoter h...

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Publicat a:BMC Cancer
Autors principals: Richter, Anna, Roolf, Catrin, Hamed, Mohamed, Gladbach, Yvonne Saara, Sender, Sina, Konkolefski, Christoph, Knübel, Gudrun, Sekora, Anett, Fuellen, Georg, Vollmar, Brigitte, Murua Escobar, Hugo, Junghanss, Christian
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404304/
https://ncbi.nlm.nih.gov/pubmed/30841886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5411-0
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