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SMAD4 Deficiency Leads to Development of Arteriovenous Malformations in Neonatal and Adult Mice
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic vascular disorder caused by mutations in endoglin (ENG), activin receptor‐like kinase 1 (ACVRL1;ALK1), or SMAD4. Major clinical symptoms of HHT are arteriovenous malformations (AVMs) found in the brain, lungs, visceral organs,...
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| Publicado no: | J Am Heart Assoc |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6404197/ https://ncbi.nlm.nih.gov/pubmed/30571376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009514 |
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