Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice

BACKGROUND: Tetrahydrobiopterin is a cofactor of endothelial NO synthase (eNOS), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects (CHDs) induc...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Engineer, Anish, Saiyin, Tana, Lu, Xiangru, Kucey, Andrew S., Urquhart, Brad L., Drysdale, Thomas A., Norozi, Kambiz, Feng, Qingping
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404194/
https://ncbi.nlm.nih.gov/pubmed/30608180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009624
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