Sapropterin Treatment Prevents Congenital Heart Defects Induced by Pregestational Diabetes Mellitus in Mice

BACKGROUND: Tetrahydrobiopterin is a cofactor of endothelial NO synthase (eNOS), which is critical to embryonic heart development. We aimed to study the effects of sapropterin (Kuvan), an orally active synthetic form of tetrahydrobiopterin on eNOS uncoupling and congenital heart defects (CHDs) induc...

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Detaylı Bibliyografya
Yayımlandı:J Am Heart Assoc
Asıl Yazarlar: Engineer, Anish, Saiyin, Tana, Lu, Xiangru, Kucey, Andrew S., Urquhart, Brad L., Drysdale, Thomas A., Norozi, Kambiz, Feng, Qingping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404194/
https://ncbi.nlm.nih.gov/pubmed/30608180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009624
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