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N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes

BACKGROUND: Pregestational diabetes is a major risk factor of congenital heart defects (CHDs). Glutathione is depleted and reactive oxygen species (ROS) production is elevated in diabetes. In the present study, we aimed to examine whether treatment with N-acetylcysteine (NAC), which increases glutat...

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Detalhes bibliográficos
Main Authors: Moazzen, Hoda, Lu, Xiangru, Ma, Noelle L, Velenosi, Thomas J, Urquhart, Brad L, Wisse, Lambertus J, Gittenberger-de Groot, Adriana C, Feng, Qingping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942143/
https://ncbi.nlm.nih.gov/pubmed/24533448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-46
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