N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes

BACKGROUND: Pregestational diabetes is a major risk factor of congenital heart defects (CHDs). Glutathione is depleted and reactive oxygen species (ROS) production is elevated in diabetes. In the present study, we aimed to examine whether treatment with N-acetylcysteine (NAC), which increases glutat...

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Bibliografiske detaljer
Main Authors: Moazzen, Hoda, Lu, Xiangru, Ma, Noelle L, Velenosi, Thomas J, Urquhart, Brad L, Wisse, Lambertus J, Gittenberger-de Groot, Adriana C, Feng, Qingping
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942143/
https://ncbi.nlm.nih.gov/pubmed/24533448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-13-46
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