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8‐Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1
BACKGROUND: 8‐Aminoguanosine and 8‐aminoguanine are K(+)‐sparing natriuretics that increase glucose excretion. Most effects of 8‐aminoguanosine are due to its metabolism to 8‐aminoguanine. However, the mechanism by which 8‐aminoguanine affects renal function is unknown and is the focus of this inves...
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| Publicado no: | J Am Heart Assoc |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6404173/ https://ncbi.nlm.nih.gov/pubmed/30608204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.010085 |
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