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Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness

Hearing loss is the most common human sensory deficit. Its correction has been the goal of several gene-therapy based studies exploring a variety of interventions. Although these studies report varying degrees of success, all treatments have targeted developing inner ears in neonatal mice, a time po...

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Vydáno v:Mol Ther
Hlavní autoři: Yoshimura, Hidekane, Shibata, Seiji B., Ranum, Paul T., Moteki, Hideaki, Smith, Richard J.H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403483/
https://ncbi.nlm.nih.gov/pubmed/30686588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.12.014
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