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Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness

Hearing loss is the most common human sensory deficit. Its correction has been the goal of several gene-therapy based studies exploring a variety of interventions. Although these studies report varying degrees of success, all treatments have targeted developing inner ears in neonatal mice, a time po...

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Bibliografiska uppgifter
I publikationen:Mol Ther
Huvudupphovsmän: Yoshimura, Hidekane, Shibata, Seiji B., Ranum, Paul T., Moteki, Hideaki, Smith, Richard J.H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403483/
https://ncbi.nlm.nih.gov/pubmed/30686588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.12.014
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