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T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1

The SUMO modification system plays an important role in T cell activation, yet how sumoylation regulates TCR-proximal signaling remains largely unknown. We show here that Phospholipase C-γ1 (PLC-γ1) is conjugated by SUMO1 at K54 and K987 upon TCR stimulation and that K54 sumoylation is pivotal for P...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Wang, Qi-Long, Liang, Jia-Qi, Gong, Bei-Ni, Xie, Ji-Ji, Yi, Yu-Ting, Lan, Xin, Li, Yingqiu
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403162/
https://ncbi.nlm.nih.gov/pubmed/30873169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00314
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