Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models

Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a novel machine learning formalism for improved sig...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Funnell, Tyler, Zhang, Allen W., Grewal, Diljot, McKinney, Steven, Bashashati, Ali, Wang, Yi Kan, Shah, Sohrab P.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402697/
https://ncbi.nlm.nih.gov/pubmed/30794536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006799
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