Prognostic Impact of Immunohistochemical p53 Expression in Bone Marrow Biopsy in Higher Risk MDS: a Pilot Study

BACKGROUND AND OBJECTIVES: Mutations of the TP53 gene have an unfavorable prognosis in Myelodysplastic Syndromes (MDS). The product of the TP53 gene is the p53 protein. Most of the TP53 mutations entail the accumulation of the protein in the nucleus of tumor cells. The immunohistochemical (IHC) stai...

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Publicat a:Mediterr J Hematol Infect Dis
Autors principals: Molteni, Alfredo, Ravano, Emanuele, Riva, Marta, Nichelatti, Michele, Bandiera, Laura, Crucitti, Lara, Truini, Mauro, Cairoli, Roberto
Format: Artigo
Idioma:Inglês
Publicat: Università Cattolica del Sacro Cuore 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402551/
https://ncbi.nlm.nih.gov/pubmed/30858953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4084/MJHID.2019.015
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