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Assessing correlates of protection in vaccine trials: statistical solutions in the context of high vaccine efficacy
BACKGROUND: The use of correlates of protection (CoPs) in vaccination trials offers significant advantages as useful clinical endpoint substitutes. Vaccines with very high vaccine efficacy (VE) are documented in the literature (VE ≥95%). The rare events (number of infections) observed in the vaccina...
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| Pubblicato in: | BMC Med Res Methodol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6402125/ https://ncbi.nlm.nih.gov/pubmed/30841856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-019-0687-y |
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