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Assessing correlates of protection in vaccine trials: statistical solutions in the context of high vaccine efficacy
BACKGROUND: The use of correlates of protection (CoPs) in vaccination trials offers significant advantages as useful clinical endpoint substitutes. Vaccines with very high vaccine efficacy (VE) are documented in the literature (VE ≥95%). The rare events (number of infections) observed in the vaccina...
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| Publicado no: | BMC Med Res Methodol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6402125/ https://ncbi.nlm.nih.gov/pubmed/30841856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-019-0687-y |
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