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Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?

The high degree of conservation of CD8 T cell epitopes of influenza A virus (IAV) may allow for the development of T cell-inducing vaccines that provide protection across different strains and subtypes. This conservation is not fully explained by functional constraint, since an additional mutation(s...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Li, Zheng-Rong Tiger, Zarnitsyna, Veronika I., Lowen, Anice C., Weissman, Daniel, Koelle, Katia, Kohlmeier, Jacob E., Antia, Rustom
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401462/
https://ncbi.nlm.nih.gov/pubmed/30626684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01534-18
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