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TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection

Transmembrane serine protease TMPRSS2 activates the spike protein of highly pathogenic human coronaviruses such as severe acute respiratory syndrome-related coronavirus (SARS-CoV) and Middle East respiratory syndrome-related coronavirus (MERS-CoV). In vitro, activation induces virus-cell membrane fu...

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Bibliografski detalji
Izdano u:J Virol
Glavni autori: Iwata-Yoshikawa, Naoko, Okamura, Tadashi, Shimizu, Yukiko, Hasegawa, Hideki, Takeda, Makoto, Nagata, Noriyo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401451/
https://ncbi.nlm.nih.gov/pubmed/30626688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01815-18
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