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PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex
The HIV-1 capsid protein (CA) facilitates reverse transcription and nuclear entry of the virus. However, CA’s role in post-nuclear entry steps remains speculative. We describe a direct link between CA and integration by employing the capsid inhibitor PF74 as a probe coupled with the biochemical anal...
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| 發表在: | J Virol |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6401427/ https://ncbi.nlm.nih.gov/pubmed/30567984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01741-18 |
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