PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex

The HIV-1 capsid protein (CA) facilitates reverse transcription and nuclear entry of the virus. However, CA’s role in post-nuclear entry steps remains speculative. We describe a direct link between CA and integration by employing the capsid inhibitor PF74 as a probe coupled with the biochemical anal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Virol
Egile Nagusiak: Balasubramaniam, Muthukumar, Zhou, Jing, Addai, Amma, Martinez, Phillip, Pandhare, Jui, Aiken, Christopher, Dash, Chandravanu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2019
Gaiak:
Virus-Cell Interactions
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401427/
https://ncbi.nlm.nih.gov/pubmed/30567984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01741-18
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