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Ca(2+)/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABA(B1) Triggers Lysosomal Degradation of GABA(B) Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination
The G protein-coupled GABA(B) receptors, constituted from GABA(B1) and GABA(B2) subunits, are important regulators of neuronal excitability by mediating long-lasting inhibition. One factor that determines receptor availability and thereby the strength of inhibition is regulated protein degradation....
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| Udgivet i: | Mol Neurobiol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer US
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6401210/ https://ncbi.nlm.nih.gov/pubmed/29881949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1142-5 |
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