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Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation
Hepatocyte-like cells (HLCs) derived from induced pluripotent stem cells (iPSCs) provide a renewable source of cells for drug discovery, disease modelling and cell-based therapies. Here, by using GRO-Seq we provide the first genome-wide analysis of the nascent RNAs in iPSCs, HLCs and primary hepatoc...
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| Pubblicato in: | Sci Rep |
|---|---|
| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6401154/ https://ncbi.nlm.nih.gov/pubmed/30837492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39215-0 |
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