Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation

Hepatocyte-like cells (HLCs) derived from induced pluripotent stem cells (iPSCs) provide a renewable source of cells for drug discovery, disease modelling and cell-based therapies. Here, by using GRO-Seq we provide the first genome-wide analysis of the nascent RNAs in iPSCs, HLCs and primary hepatoc...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Viiri, Leena E., Rantapero, Tommi, Kiamehr, Mostafa, Alexanova, Anna, Oittinen, Mikko, Viiri, Keijo, Niskanen, Henri, Nykter, Matti, Kaikkonen, Minna U., Aalto-Setälä, Katriina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401154/
https://ncbi.nlm.nih.gov/pubmed/30837492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39215-0
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