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Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) results from a CAG repeat expansion within the androgen receptor gene (AR). It is unclear why motor neurons selectively degenerate and there are currently no treatments for this debilitating disease. To uncover the causative genes and pathways involved in mo...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Malik, Bilal, Devine, Helen, Patani, Rickie, La Spada, Albert R., Hanna, Michael G., Greensmith, Linda
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401132/
https://ncbi.nlm.nih.gov/pubmed/30837566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40118-3
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