Cooperative Changes in Solvent Exposure Identify Cryptic Pockets, Switches, and Allosteric Coupling

Proteins are dynamic molecules that undergo conformational changes to a broad spectrum of different excited states. Unfortunately, the small populations of these states make it difficult to determine their structures or functional implications. Computer simulations are an increasingly powerful means...

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Vydáno v:Biophys J
Hlavní autoři: Porter, Justin R., Moeder, Katelyn E., Sibbald, Carrie A., Zimmerman, Maxwell I., Hart, Kathryn M., Greenberg, Michael J., Bowman, Gregory R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400826/
https://ncbi.nlm.nih.gov/pubmed/30744991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.11.3144
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