Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina

Mutations in the retinal protein retinoschisin (RS1) cause progressive loss of vision in young males, a form of macular degeneration called X-linked retinoschisis (XLRS). We previously solved the structure of RS1, a 16-mer composed of paired back-to-back octameric rings. Here, we show by cryo–electr...

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Опубликовано в: :J Cell Biol
Главные авторы: Heymann, J. Bernard, Vijayasarathy, Camasamudram, Huang, Rick K., Dearborn, Altaira D., Sieving, Paul A., Steven, Alasdair C.
Формат: Artigo
Язык:Inglês
Опубликовано: Rockefeller University Press 2019
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400569/
https://ncbi.nlm.nih.gov/pubmed/30630865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201806148
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