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Paired octamer rings of retinoschisin suggest a junctional model for cell–cell adhesion in the retina

Retinoschisin (RS1) is involved in cell–cell junctions in the retina, but is unique among known cell-adhesion proteins in that it is a soluble secreted protein. Loss-of-function mutations in RS1 lead to early vision impairment in young males, called X-linked retinoschisis. The disease is characteriz...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tolun, Gökhan, Vijayasarathy, Camasamudram, Huang, Rick, Zeng, Yong, Li, Yan, Steven, Alasdair C., Sieving, Paul A., Heymann, J. Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868477/
https://ncbi.nlm.nih.gov/pubmed/27114531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519048113
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