Human SPG11 cerebral organoids reveal cortical neurogenesis impairment

Spastic paraplegia gene 11(SPG11)-linked hereditary spastic paraplegia is a complex monogenic neurodegenerative disease that in addition to spastic paraplegia is characterized by childhood onset cognitive impairment, thin corpus callosum and enlarged ventricles. We have previously shown impaired pro...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Pérez-Brangulí, Francesc, Buchsbaum, Isabel Y, Pozner, Tatyana, Regensburger, Martin, Fan, Wenqiang, Schray, Annika, Börstler, Tom, Mishra, Himanshu, Gräf, Daniela, Kohl, Zacharias, Winkler, Jürgen, Berninger, Benedikt, Cappello, Silvia, Winner, Beate
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400051/
https://ncbi.nlm.nih.gov/pubmed/30476097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy397
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