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Exploring the Role of the Third Active Site Metal Ion in DNA Polymerase η with QM/MM Free Energy Simulations
The enzyme human DNA polymerase η (Pol η) is critical for bypassing lesions during DNA replication. In addition to the two Mg(2+) ions aligning the active site, experiments suggest that a third Mg(2+) ion could play an essential catalytic role. Herein the role of this third metal ion is investigated...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6399739/ https://ncbi.nlm.nih.gov/pubmed/29932331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05177 |
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