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Alder-ene reactions driven by high steric strain and bond angle distortion to form benzocyclobutenes

A unique aryne-based Alder-ene reaction to form benzocyclobutene is described. In this process, the thermodynamic barrier to form a four-membered ring is compensated by the relief of the strain energy of an aryne intermediate. On the other hand, the driving force to overcome the high kinetic barrier...

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Publicado en:Chem Sci
Autores principales: Gupta, Saswata, Lin, Yongjia, Xia, Yuanzhi, Wink, Donald J., Lee, Daesung
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399677/
https://ncbi.nlm.nih.gov/pubmed/30931094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc04277b
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