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Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease
Sphingosine phosphate lyase (SPL) is the final enzyme in the sphingolipid degradative pathway, catalyzing the irreversible cleavage of long-chain base phosphates (LCBPs) to yield a long-chain aldehyde and ethanolamine phosphate (EP). SPL guards the sole exit point of sphingolipid metabolism. Its ina...
Gardado en:
| Publicado en: | J Lipid Res |
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| Autor Principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6399507/ https://ncbi.nlm.nih.gov/pubmed/30635364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.S091181 |
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