A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha

The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key regulator of lipid transfer in ER-membrane contact sites. Four different phosphatidylinositol 4-kinase (PI4K) enzymes generate PI4P in different membrane compartments supporting distinct cellular processes, many of...

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Vydáno v:J Lipid Res
Hlavní autoři: Sengupta, Nivedita, Jović, Marko, Barnaeva, Elena, Kim, David W., Hu, Xin, Southall, Noel, Dejmek, Milan, Mejdrova, Ivana, Nencka, Radim, Baumlova, Adriana, Chalupska, Dominika, Boura, Evzen, Ferrer, Marc, Marugan, Juan, Balla, Tamas
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2019
Témata:
Methods
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399489/
https://ncbi.nlm.nih.gov/pubmed/30626625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.D090159
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