CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival

A transplanted organ is always rejected in the absence of any immunosuppressive treatment due to vigorous alloimmunity. However, continuously global immunosuppression with a conventional immunosuppressant may result in severe side effects, including nephrotoxicity, tumors and infections. Tregs have...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Liu, Huazhen, Qiu, Feifei, Wang, Yuanzhong, Zeng, Qiaohuang, Liu, Cuihua, Chen, Yuchao, Liang, Chun-Ling, Zhang, Qunfang, Han, Ling, Dai, Zhenhua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399415/
https://ncbi.nlm.nih.gov/pubmed/30863408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00306
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