Blocking α(2)δ-1 Subunit Reduces Bladder Hypersensitivity and Inflammation in a Cystitis Mouse Model by Decreasing NF-kB Pathway Activation

Bladder pain is frequently associated with bladder inflammation, as in conditions like interstitial cystitis (IC), for which current analgesic therapies have limited efficacy. The antinociceptive effect of alpha-2-delta (α(2)δ) ligands on inflammation-associated visceral pain like that experienced i...

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Vydáno v:Front Pharmacol
Hlavní autoři: Boudieu, Ludivine, Mountadem, Sarah, Lashermes, Amandine, Meleine, Mathieu, Ulmann, Lauriane, Rassendren, François, Aissouni, Youssef, Sion, Benoit, Carvalho, Frédéric Antonio, Ardid, Denis
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399165/
https://ncbi.nlm.nih.gov/pubmed/30863309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00133
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