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A Bayesian design for phase I cancer therapeutic vaccine trials

Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of ca...

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Bibliografski detalji
Izdano u:Stat Med
Glavni autori: Wang, Chenguang, Rosner, Gary L., Roden, Richard B.S.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399043/
https://ncbi.nlm.nih.gov/pubmed/30368868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8021
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