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A Bayesian design for phase I cancer therapeutic vaccine trials

Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of ca...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stat Med
Prif Awduron: Wang, Chenguang, Rosner, Gary L., Roden, Richard B.S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399043/
https://ncbi.nlm.nih.gov/pubmed/30368868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8021
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