Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes

Liver development involves dramatic gene expression changes mediated by transcriptional and post-transcriptional control. Here, we show that the Cnot deadenylase complex plays a crucial role in liver functional maturation. The Cnot3 gene encodes an essential subunit of the Cnot complex. Mice lacking...

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Bibliografiske detaljer
Udgivet i:Development
Main Authors: Suzuki, Toru, Kikuguchi, Chisato, Nishijima, Saori, Nagashima, Takeshi, Takahashi, Akinori, Okada, Mariko, Yamamoto, Tadashi
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398447/
https://ncbi.nlm.nih.gov/pubmed/30733279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.168146
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