Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

BACKGROUND: With an increasing indication spectrum of antiresorptive drugs, the medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy [MRONJ (BP)] is continuously gaining clinical relevance. Impaired osteoclast function, accompanied by altered cell morphology and expression...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Wehrhan, Falk, Gross, Christian, Creutzburg, Kay, Amann, Kerstin, Ries, Jutta, Kesting, Marco, Geppert, Carol-Immanuel, Weber, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398259/
https://ncbi.nlm.nih.gov/pubmed/30832685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1819-1
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