Expression of Msx-1 is suppressed in bisphosphonate associated osteonecrosis related jaw tissue-etiopathology considerations respecting jaw developmental biology-related unique features

BACKGROUND: Bone-destructive disease treatments include bisphosphonates and antibodies against the osteoclast differentiator, RANKL (aRANKL); however, osteonecrosis of the jaw (ONJ) is a frequent side-effect. Current models fail to explain the restriction of bisphosphonate (BP)-related and denosumab...

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Detalhes bibliográficos
Main Authors: Wehrhan, Falk, Hyckel, Peter, Ries, Jutta, Stockmann, Phillip, Nkenke, Emeka, Schlegel, Karl A, Neukam, Friedrich W, Amann, Kerstin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2973937/
https://ncbi.nlm.nih.gov/pubmed/20942943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-96
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